British No.1 and sixth seed Murray destroyed Argentina's Sergio Roitman 6-3, 6-4, 6-0 in an hour and 35 minutes at New York's Flushing Meadow to bounce back from a first-round defeat by world number 77 Lu Yen-Hsun at the Games.
The Scot, ranked number six in the world, will now play either Michael Llodra of France or Russia’s Teimuraz Gabashvili in the second round.
Murray met with little resistance from the clay specialist boasting only one win
this year on hard courts.