The keeper will make a decision this morning after suffering a sore back following Wednesday's Champions League victory in Moscow.
Van der Sar's return has helped stabilise the defence after Ben Foster dropped a couple of high-profile clangers and Sir Alex Ferguson will be keen to have somebody available who he described as the best in the business this week.
"Edwin is a fantastic goalkeeper," said Ferguson.
"It was interesting recently that Ruud Gullit claimed he is the best goalkeeper in the world.
"He got no argument from his fellow panellists, and I think his argument is quite right - just look at Edwin's record over the years, his composure and organisational ability.
"He does make a difference to us."
The Dutch veteran did make a huge mistake in gifting Liverpool an equaliser in last year's fixture on Merseyside when Wes Brown scored an own goal but his presence would be sorely missed in the white-hot atmosphere.
Tomasz Kuszczak has been placed on standby, although Foster would obviously be the other option for the Anfield encounter if the number one is ruled out.
Meanwhile, midfielder Darren Fletcher has been wearing a plastic air boot due to an ankle injury.
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This article has 2 comments
Stephen, I bet Sir Alex is so relieved that youre here to give your support. It wouldnt be possible without people like you. Well done.
By matinus.. Posted October 25 2009 at 8:48 AM.
Wel i thnk sir Alex should make the rite decision by chosing who to keep for todays match & i'l personal advice him to use foster to van dar sar
By Stephen .. Posted October 25 2009 at 8:21 AM.