Leeds trailed to a try by Chris Melling after four minutes but hit back with tries from Kevin Sinfield and Danny McGuire to lead 12-4.
After David Howell scored for Quins Jamie Jones-Buchanan replied. And following the break the visitors added two more through Scott Donald and Brent Webb.
Then they piled on the misery with tries from Danny Buderus, Lee Smith and Ryan Hall. Sinfield added eight goals for a personal tally of 20 points.
Chad Randall got the Quins' only second-half try.
SCORERS - Harlequins: tries Melling, Howell, Randall; goals Orr. Leeds: tries Sinfield, McGuire, Jones-Buchanan, Donald, Webb, Buderus, Smith, Hall; goals Sinfield 7, Senior.
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